Study on the ADC value of deep gray matter nuclei in patients with Parkinson's disease by RESOLVE DWI
10.3969/j.issn.1671-8348.2025.04.022
- VernacularTitle:高清扩散加权成像对帕金森病患者脑深部灰质核团的价值研究
- Author:
Lishu ZHU
1
;
Xinyou LI
;
Bin YU
;
Yunfeng LU
;
Zhiwei ZHANG
;
Yongmei LI
;
Fajin LYU
;
Silin DU
Author Information
1. 重庆医科大学附属第一医院放射科,重庆 400016
- Keywords:
Parkinson's disease;
deep gray matter nuclear mass;
readout segmentation of long variable echo-trains diffusion weighted imaging;
apparent diffusion coefficient
- From:
Chongqing Medicine
2025;54(4):915-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective Readout segmentation of long variable echo-trains diffusion weighted imaging(RESOLVE DWI)was used to analyze the difference of apparent diffusion coefficient(ADC)value in deep cerebral nucleus and its correlation with clinical characteristics in patients with Parkinson's disease(PD).Methods Clinical data of 60 patients with PD were retrospectively analyzed as PD group,and were divided in-to the tremor group(n=30)and the bradykinesia group(n=30)according to symptom type,middle-aged(≤65 years old)group(n=23)and elderly(＞65 years old)group(n=37)according to age,and 60 healthy vol-unteers were selected as the control group during the same period.ADC values were measured on the ADC map of RESOLVE DWI sequence,and the ADC values of bilateral putamen,pallidus,substantia nigra,rubra,and dentate nucleus were analyzed and their correlation with UPDRS-Ⅲ score and H&Y grading.Results Compared with the control group,the ADC values of both putamen,globus pallidus,globus pallidus,red nucleus,right substantia nigra and right dentate nucleus were increased in the PD group,the ADC values of both putamen,globus pallidus,red nucleus and right substantia nigra in the tremor group were increased,and the ADC values of right putamen,globus pallidus and bilateral red nucleus in the bradykinesia group were increased(P＜0.05).Compared with the bradykinesia group,the values of ADC in the tremor group were similar.Compared with the middle-aged group,the ADC values of right putamen,bilateral globus pallidus,left substantia nigra and left red nucleus were higher in the elderly group(P＜0.05).In the PD group,the ADC values of the right putamen,globus pallidus,and dentate nucleus were positively correlated with H&Y grade and UPDRS-Ⅲscore,and the ADC value of the left putamen was positively correlated with H&Y grade.Conclusion RE-SOLVE DWI can be used to evaluate the differences in deep gray matter nuclei in PD patients,and its ADC value may be used to evaluate and predict the severity of nuclear mass damage and motor symptoms in PD pa-tients.
