Study on the diagnostic value of ultra-fast dynamic contrast enhanced MRI for molecular subtypes of breast cancer
10.3969/j.issn.1671-8348.2025.04.017
- VernacularTitle:超快速动态对比增强MRI对乳腺癌分子亚型的诊断价值研究
- Author:
Lan LI
1
;
Xiaoxia WANG
;
Tao YU
;
Jiuquan ZHANG
Author Information
1. 重庆大学附属肿瘤医院影像科,重庆 400030
- Keywords:
breast neoplasms;
triple negative breast neoplasms;
magnetic resonance imaging;
dynamic contrast-enhanced magnetic resonance imaging;
molecular subtype
- From:
Chongqing Medicine
2025;54(4):889-892,897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the performance of ultrafast dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in distinguishing breast cancer molecular subtypes.Methods A total of 129 breast cancer patients undergoing ultra-rapid DCE-MRI were analyzed.According to the pathological results,the patients were divided into lumen type,human epidermal growth factor receptor 2(HER2)overexpression type and triple negative type.Ultrafast DCE-MRI parameters of the three groups were compared.Receiver op-erating characteristic(ROC)curve was used to evaluate the performance of ultra-fast DCE-MRI parameters in identifying different molecular subtypes of breast cancer.Results The maximum slope(MS),peak enhance-ment intensity(PEI)and area under initial ROC curve(iAUC)of the three molecular subtypes were signifi-cantly different in ultra-fast DCE-MRI parameters(P＜0.05).The MS,PEI and iAUC of triple-negative and HER2-overexpressed breast cancer were significantly higher than those of lumen breast cancer(P＜0.05).The AUC for MS,PEI and iAUC were 0.765,0.702 and 0.775,respectively.The AUC for MS,PEI and iAUC were 0.767,0.684 and 0.784,respectively.Conclusion Ultrafast DCE-MRI parameters can be the potential image markers to identify TNBC and luminal subtype.
