Study on the effects of different dialysis modalities on sex hormone levels and menstrual patterns in childbearing-age women with uremia
10.3969/j.issn.1671-8348.2025.04.006
- VernacularTitle:不同透析方式对尿毒症育龄期女性患者性激素水平及月经的影响研究
- Author:
Yi WU
1
;
Zhihua SUN
;
Ning SHAO
Author Information
1. 武汉科技大学医学部,武汉 430065;天门市第一人民医院肾内科,湖北天门 431700
- Keywords:
uremia;
hemodialysis;
peritoneal dialysis;
sex hormones;
menstrual disorders
- From:
Chongqing Medicine
2025;54(4):830-834
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different dialysis modalities on hormonal profiles and menstrual disorders in childbearing-age women with uremia.Methods From March 2020 to July 2024,102 childbearing-age women with uremia treated in the Department of Nephrology of Tianmen First People's Hospital were enrolled and divided into hemodialysis group(n=52)and peritoneal dialysis group(n=50),and 50 healthy women undergoing physical examinations were selected as the control group.Sex hormone lev-els and menstrual patterns were compared among three groups at baseline and 6 months post-dialysis.Results Pre-treatment levels of follicle-stimulating hormone(FSH),prolactin(PRL),and luteinizing hormone(LH)in both hemodialysis and peritoneal dialysis groups were significantly higher than those in healthy controls,while progesterone(P)levels were lower(P＜0.05).Post-treatment,hemodialysis and peritoneal dialysis groups showed decreased FSH and increased LH,PRL,and P compared to baseline(P＜0.05).Estradiol(E2)and P levels in hemodialysis group were slightly lower than those in the peritoneal dialysis group without statistical significance(P＞0.05).No significant intergroup differences existed in FSH,LH,P,or PRL between hemodi-alysis and peritoneal dialysis groups post-treatment(P＞0.05).Menstrual normalization and disorder rates in hemodialysis group were nonsignificantly lower than peritoneal dialysis group(P＞0.05),whereas amenor-rhea incidence was significantly higher in hemodialysis group(P＜0.05).Menstrual resumption rate after a-menorrhea showed no statistical difference between groups(P＞0.05).Conclusion Both peritoneal dialysis and hemodialysis effectively ameliorate hormonal dysregulation in female uremia patients,while peritoneal dialysis demon-strates superior efficacy in improving menstrual disorders.
