Research progress on mechanism of valproic acid in treatment of spinal cord injury
10.3969/j.issn.1671-8348.2025.03.039
- VernacularTitle:丙戊酸治疗脊髓损伤作用机制的研究进展
- Author:
Yibing KE
1
;
Haoran GUO
;
Yongping WANG
Author Information
1. 兰州大学第一临床医学院,兰州 730000
- Keywords:
spinal cord injury;
valproic acid;
signaling pathways
- From:
Chongqing Medicine
2025;54(3):779-785
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury(SCI)can result in varying degrees of spinal motor dysfunction,partial sensory loss and sphincter dysfunction.SCI is divided into two stages:primary injury and secondary injury.The spinal cord cell necrosis during the primary injury period and apoptosis,oxidative stress and autophagy during the secondary injury period lead a large number of cell injury and permanant neurodysfunction.The histone deacetylase(HDAC)plays a key role in regulating the cellular viability and gene transcription.Neuro-dysfunction induced by SCI is associated with transcriptional dysfunction associated with unbalanced levels of protein acetylation.Valproic acid(VPA)is a inhibitor of HDAC and is usually used as an antiepileptic drug in clinic.Studies show that VPA may have the potential to treat the central nervous system diseases.VPA inhib-its HDAC,and then regulates oxidative stress,cellular autophagy,ion imbalance,microglia differentiation and inflammatory response,and plays the neuroprotective effect.This paper reviewed the related molecular mecha-nism of VPA in treating SCI.
