Research advances in IP3R calcium ion channels and respiratory system-related diseases
10.3969/j.issn.1671-8348.2025.03.037
- VernacularTitle:IP3R钙离子通道与呼吸系统相关疾病的研究进展
- Author:
Xinyun XIE
1
;
Yan HUANG
;
Ao DANG
;
Rong HUA
;
Jiachun ZHANG
;
Zhao YANG
Author Information
1. 成都市第六人民医院呼吸肿瘤科,成都 610051
- Keywords:
calcium ion;
inositol 1,4,5-trisphosphate receptor;
respiratory diseases
- From:
Chongqing Medicine
2025;54(3):770-774
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of respiratory diseases such as chronic obstructive pulmonary disease(COPD),asthma,and pulmonary hypertension remains incompletely understood.However,accumulating evi-dence suggests that calcium ion channels play a critical role in these disorders.As a key second messenger,cal-cium ions regulates diverse physiological and pathological processes.Studies indicate that calcium ion homeo-stasis,including their concentration and distribution and spatial distribution is mediated primarily through ino-sitol 1,4,5-trisphosphate receptor(IP3R)channel.Disruption of this homeostasis may contribute to the devel-opment of COPD,asthma,and other respiratory diseases.Nevertheless,the role of IP3R channels in respirato-ry diseases require further investigation.
