Research progress on P2X7 receptor in cardiovascular diseases
10.3969/j.issn.1671-8348.2025.03.032
- VernacularTitle:P2X7受体在心血管疾病中的研究进展
- Author:
Shuhong ZHANG
1
;
Yanhong TANG
Author Information
1. 武汉大学人民医院心内科/武汉大学心血管病研究所/心血管病湖北省重点实验室,武汉 430060
- Keywords:
P2X7 receptor;
adenosine triphosphate;
inflammation;
myocardial infarction;
atherosclero-sis;
hypertension
- From:
Chongqing Medicine
2025;54(3):744-749
- CountryChina
- Language:Chinese
-
Abstract:
The P2X7 receptor,a ligand-gated ion channel in the purinergic receptor family,is widely ex-pressed in various tissues and organs.Its structure is significantly different from other subtypes.This struc-tural specificity confers low adenosine triphosphate(ATP)binding affinity and two distinct characteristics:ion channel function under short-term/low-concentration ATP stimulation,and formation of non-selective pores with current facilitation during prolonged/high-concentration ATP exposure.Inflammatory responses are in-volved in the pathophysiological processes of various cardiovascular diseases.Substantial evidence indicates that P2X7 receptor activation participates in the pathophysiological processes of myocardial infarction,athero-sclerosis,hypertension,and cardiomyopathy..Receptor activation potentiates chronic inflammatory cascades,mechanistically contributing to myocardial infarction,atherosclerosis,hypertension,and cardiomyopathy pro-gression.This review summarizes the structure and function of P2X7 receptors and their mechanisms in vari-ous cardiovascular diseases.
