Research progress of ribosomal protein in drug resistance in cancer treatment
10.3969/j.issn.1671-8348.2025.03.031
- VernacularTitle:核糖体蛋白在癌症治疗耐药中的研究进展
- Author:
Zhui CHEN
1
;
Qiuling JIE
;
Mingyao LIU
;
Yanlin MA
Author Information
1. 海南医科大学,第一附属医院,海南医科大学衰老与肿瘤国际研究中心,生殖健康及相关疾病研究与转化教育部重点实验室,生殖医学中心,海南省人类生殖与遗传重点实验室,海口 571199
- Keywords:
ribosomal protein;
tumor drug resistance;
epithelial mesenchymal transformation;
signal path;
tumor microenvironment
- From:
Chongqing Medicine
2025;54(3):738-743,749
- CountryChina
- Language:Chinese
-
Abstract:
Ribosomal protein(RP)is an important part of ribosome,which is very important for the assembly and function of ribosome.Recent studies have shown that RP is closely related to the processes of growth,senescence,apoptosis,invasion and drug resistance of tumor cells.The drug resistance of tumors is one of the main reasons for the low cure rate of tumors.RP can affect the drug resistance of tumor cells through a variety of mechanisms,such as changes in signal pathway,epithelial-mesenchymal transformation,cancer stem cells and tumor microenvironment,resulting in a poor prognosis of cancer patients.Ribosome tar-geting therapy is a promising method for the treatment of cancer patients.This review summarizes the mecha-nism of RP and many kinds of cancer drug resistance,provides new ideas for elucidating the mechanism of tumor drug resistance,and then provides new strategies for clinical prevention and reduction of tumor drug re-sistance.
