The effect of preparing PRF at different centrifugal speeds on tooth extraction wounds:a network meta-analysis
10.3969/j.issn.1671-8348.2025.03.025
- VernacularTitle:不同离心转速下制备的PRF在拔牙创中应用效果的网状meta分析
- Author:
Jiandong ZHU
1
;
Wanyu HU
;
Hang ZHANG
;
Jinsong ZHANG
Author Information
1. 重庆医科大学附属第一医院颌面外科,重庆 400016
- Keywords:
platelet-rich fibrin;
tooth extraction;
efficacy;
net work meta analysis;
randomized con-trolled trial
- From:
Chongqing Medicine
2025;54(3):701-708
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the application effect of platelet rich fibrin(PRF)prepared at different centrifugal speeds in tooth extraction wounds using network meta-analysis statistical method.Methods PubMed,Co-chrane Library,Embase,Web of Science,CNKI,Wanfang,VIP and China Biology Medicine disc(CBM)databases were searched to collect the randomized controlled trials on the effect of PRF in tooth extraction from January 1,2024.Note-Express software was used to select literatures,RevMan5.3 was used to evaluate the quality of the included literatures,and Stata14.0 software was used to perform mesh meta-analysis on outcome indicators such as bone mineral density,bone height loss,visual analog scale of pain(VAS),dry groove,and bleeding after tooth extraction.Results A total of 31 randomized controlled trials were included,including 2 824 extraction sites,involving 7 rotational speeds for PRF preparation(3 000,2 800,2 700,2 300,1 500,1 400,1 300 r/min).The results of cu-mulative sequencing showed that PRF prepared by 2 700 r/min centrifugation had the best effect in improving bone mineral density.In terms of improving the buccal bone height,the PRF prepared by 2 700 r/min centrifu-gation had the best effect.In terms of pain improvement,PRF prepared by 1 500 r/min centrifugation had the best effect;PRF prepared by 2 500 r/min centrifugation had the best effect in reducing the incidence of dry trough.PRF prepared by 2 500 r/min centrifugation was the most effective in reducing bleeding.Conclusion Based on the available evidence,PRF prepared with 2 700 r/min has the best effect on improving bone density and bone height after tooth extraction.In terms of pain improvement,1 500 r/min was the most effective;2 500 r/min was the most effective in improving the incidence of dry trough and bleeding.
