Correlation between gut microbiota and diffuse large B-cell lymphoma based on Mendelian randomization
10.3969/j.issn.1671-8348.2025.03.017
- VernacularTitle:基于孟德尔随机化探究肠道菌群与弥漫大B细胞淋巴瘤的相关性
- Author:
Juan LIU
1
;
Mingliang CHEN
;
Liping HUANG
;
Wei YIN
;
Xinlu LIN
;
Yanqiu LI
;
Xin WANG
Author Information
1. 遂宁市中心医院血液科,四川 遂宁 629000
- Keywords:
diffuse large B-cell lymphoma;
gut microbiota;
Mendelian randomization;
single nucleotide polymorphism;
instrumental variable
- From:
Chongqing Medicine
2025;54(3):652-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between gut microbiota and diffuse large B-cell lymphoma(DLBCL).Methods Employed a two-sample bidirectional Mendelian randomization approach,using summary statistics from genome-wide association studies(GWAS)to extract single nucleotide polymor-phisms(SNPs)associated with exposure and outcome as instrumental variables.Exposure instrumental varia-bles(P＜1×10-5)and outcome instrumental variables(P＜5×10-8)were selected based on the P-values of SNPs.Three different Mendelian randomization methods were used to analyze the relationship between gut microbiota and DLBCL,with sensitivity analyses including heterogeneity,pleiotropy,and leave-one-out tests.Results Bilophila(OR=2.043,95%CI:1.279-3.264),Coprobacter(OR=1.371,95%CI:1.035-1.816),Eubacterium eligens group(OR=1.996,95%CI:1.291-3.087)increased the risk of DLBCL.Alistipes(OR=0.588,95%CI:0.359-0.963),Eubacterium eligens group(OR=1.996,95%CI:1.291-3.087),Slackia(OR=0.688,95%CI:0.479-0.988)reduced the risk of DLBCL.Reverse Mendelian randomization a-nalysis failed to reveal any evidence of a causal relationship between DLBCL and the six gut microbiota.Con-clusion There is a causal association between gut microbiota and DLBCL.
