Clinical study on Compound Huzhang Prescription in the treatment of dampness-heat accumulation type metabolic associated fatty liver disease
10.3969/j.issn.1671-8348.2025.03.008
- VernacularTitle:复方虎杖方治疗湿热蕴结型代谢相关脂肪性肝病的临床研究
- Author:
Chenxi GUO
1
;
Hongjie DI
;
Dan WANG
Author Information
1. 南京中医药大学第二附属医院内分泌科,南京 210017
- Keywords:
metabolic associated fatty liver disease;
Compound Huzhang Prescription;
fibroblast growth factor 21;
β-Klotho
- From:
Chongqing Medicine
2025;54(3):606-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and mechanism of the Compound Huzhang Prescription in the treatment of dampness-heat accumulation type metabolic-associated fatty liver disease(MAFLD).Methods Eighty MAFLD patients were randomly divided into the treatment group(treated with Compound Huzhang Prescription)and the control group(treated with polyene phosphatidylcholine capsules),with 40 cases in each group.After 3 months of treatment,liver function indicators(ALT,AST,γ-GGT),fast-ing blood glucose(FBG),lipid profiles(TC,TG,HDL-C,LDL-C),hepatic steatosis index(HSI),fibroblast growth factor 21(FGF21),β-Klotho(KBL),homeostasis model assessment of insulin resistance(HOMA-IR)index,and liver fat content measured by MRI were compared between pre-and post-treatment.The efficacy of traditional Chinese medicine(TCM)syndrome was evaluated based on TCM syndrome scores,and the total effective rates of the two groups were compared.Results Two cases dropped out from the treatment group and one from the control group,leaving 38 cases in the treatment group and 39 cases in the control group.The levels of liver function indicators decreased significantly in both groups after treatment compared with those before treatment(P＜0.05).After treatment,TG in the treatment group showed significant decrease com-pared with both pre-treatment level and the control group(P＜0.05).In the control group,there were no significant differences in HSI,FGF21,KBL,HOMA-IR index,or liver fat content before and after treatment(P＞0.05).However,in the treatment group,HSI,FGF21,HOMA-IR,and liver fat content significantly de-creased,while KBL significantly increased after treatment(P＜0.05).Post-treatment,all these indicators in the treatment group showed significant improvement when compared to the control group(P＜0.05).The to-tal effective rate of TCM syndrome efficacy was 81.6%in the treatment group and 46.2%in the control group,with a statistically significant difference between the two groups(P＜0.05).Conclusion The Com-pound Huzhang Prescription is effective in treating MAFLD,and its mechanism is related to alleviating FGF21 resistance.
