Serum KL-6 expression in anti-MDA5-positive juvenile dermatomyositis with interstitial lung disease
10.3969/j.issn.1671-8348.2025.03.006
- VernacularTitle:KL-6在抗MDA5阳性幼年皮肌炎伴肺间质病变患儿血清中的表达研究
- Author:
Yutong GAO
1
;
Tianping CHEN
;
Peng HU
Author Information
1. 安徽医科大学第一附属医院儿科,合肥 230022;安徽省儿童医院儿童风湿科,合肥 230051
- Keywords:
juvenile dermatomyositis;
Krebs Von den Lungen-6;
anti-melanoma differentiation associ-ated gene 5;
interstitial lung disease;
rapidly progressive pulmonary intestital lesions;
child
- From:
Chongqing Medicine
2025;54(3):593-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Krebs Von den Lungen-6(KL-6)in serum of children with anti-melanoma differentiation associated gene 5(MDA5)positive juvenile dermatomyositis(JDM)complicated with interstitial lung disease(ILD)and its clinical significance.Methods Thirty children with anti-MDA5-positive JDM who were admitted to the rheumatology Department of Anhui Children's Hos-pital from January 2020 to December 2023 were selected as the study objects.The children were divided into the ILD group(n=15)and the non-ILD group(n=15)according to whether they had concurrent ILD.Then,the subjects with rapid progressive interstitial lung disease(RP-ILD)in the ILD group were classified as the RP-ILD group(n=5).The expression level of serum KL-6 was detected by chemiluminescence method,and the difference of KL-6 level among the three groups was analyzed,as well as the correlation with clinical indi-cators.Results The level of KL-6 in the RP-ILD group was higher than that in the ILD group(n=10)and the non-ILD group[1 345.22(988.40,1 744.20)U/mL vs.578.00(441.50,845.50)U/mL vs.278.23(145.50,345.20)U/mL],the difference was statistically significant(P＜0.05).The level of KL-6 in the ILD group(n=15)after treatment was significantly lower than that before treatment[(323.89±134.19)U/mL vs.(825.12±320.02)U/mL],the difference was statistically significant(P＜0.05).There was a positive correlation between KL-6 level and serum ferritin level(P＜0.05).Conclusion KL-6 was highly expressed in serum of anti-MDA5 positive JDM children complicated with ILD.
