Analysis on clinical efficacy of dual plasma molecular adsorbent sequential plasma exchange in treatment of liver failure
10.3969/j.issn.1671-8348.2025.03.005
- VernacularTitle:双重血浆分子吸附序贯血浆置换治疗肝衰竭的临床疗效分析
- Author:
Qian LIU
1
;
Rong CHEN
;
Mingdan LI
;
Ying ZHANG
;
Mei DAI
;
Yali XU
;
Ping YANG
;
Yawen LUO
Author Information
1. 遵义医科大学附属医院护理部,贵州遵义 563000;遵义医科大学附属医院感染科,贵州遵义 563000;遵义医科大学护理学院,贵州遵义 563000
- Keywords:
liver failure;
double plasma molecular adsorption;
plasma exchange;
artificial liver;
coagula-tion function
- From:
Chongqing Medicine
2025;54(3):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of dual plasma molecular adsorption(DPMAS)sequential plasma exchange(PE)artificial liver mode in the treatment of liver failure(LF).Methods Eighty-five patients with LF receiving the artificial liver treatment in the Affiliated Hospital of Zunyi Medical Univer-sity from January 2020 to December 2023 were selected as the study subjects and divided into the study group(n=52)and the control group(n=33)according to the different treatment modes.The study group conduc-ted DPMAS sequential PE treatment and the control group underwent the PE treatment.The liver function[total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum albumin(ALB),globulin(GLO),prealbumin(PAB)],Hb,coagulation function[platelet(PLT),plasminogen activity(PTA),international normalized ratio(INR),fibrinogen(FIB)]before treatment and at 24 h after treatment were compared between the two groups.Results Compared with before treatment,the levels of TBIL,ALT,AST,GLO and Hb after the first and second treatment in the two groups were decreased,ALB level in the control group and PAB level after the second time treatment was increased(P＜0.05).Compared with after the first treatment,the levels of TBIL,ALT and GLO after the second treatment in the two groups and the levels of AST and Hb in the study group were decreased,ALB level in the study group and PAB level in the two groups were increased(P＜0.05).Compared with before treatment,the levels of PLT and FIB after the first treatment in the two groups and INR level in the control group were decreased,PTA level in the control group was increased(P＜0.05).Compared with before treatment,the levels of PLT,INR and FIB after the second treatment in the two groups were decreased,PTA level was increased(P＜0.05).Compared with be-fore treatment,the levels of PLT,INR and FIB after the second treatment in the two groups were decreased,and PTA level was increased(P＜0.05).Compared with after the first treatment,PTA level after the second treatment in the study group was increased and INR level was decreased.Conclusion PE and DPMAS sequen-tial PE all could improve the liver function in the patients with LF,moreover the two times treatment has more significant effect.
