Research advance in leukocytolower therapy for hyperleukocytic acute leukemia
10.3969/j.issn.1671-8348.2025.02.045
- VernacularTitle:高白细胞急性白血病降白细胞治疗的研究进展
- Author:
Herui YUAN
1
;
Pengxiang GUO
;
Kaiqi LIU
Author Information
1. 贵州医科大学临床医学院,贵阳 550002
- Keywords:
acute leukemia;
high white blood cell count;
early death;
genetic mutations;
prognosis
- From:
Chongqing Medicine
2025;54(2):549-555
- CountryChina
- Language:Chinese
-
Abstract:
Hyperleukocytic actue leukaemia served as an acute and critical disease of the blood system,its fatality rate can be as high as 20%-30%,and the systemic treatment should be carried out immediately af-ter diagnosis.At present,a number of studies at home and abroad have confirmed that the patients with hyper-leukocytic acute leukemia can achieve a similar remission rate and prognosis as the patients with non-hyperleu-kocytic acute leukemia after effective leukocyte lowering pretreatment.This article discussed the aspects such as the mechanism of leukemia cytosis and leukocyte lowering pretreatment therapy,in order to provide a theoretical basis for the clinical diagnosis,treatment and research of this malignant hematological cancer.
