Research progress of multidrug-resistant bacterial bloodstream infection after hematopoietic stem cell transplantation

VernacularTitle:造血干细胞移植后多重耐药菌血流感染的研究进展
Author: Ruonan ZHANG ¹ ; Lin LIU
Author Information

1. 重庆医科大学附属第一医院血液内科,重庆 400016
Keywords: hematopoietic stem cell transplantation; multidrug-resistant bacteria; bloodstream infec-tion; infection management
From: Chongqing Medicine 2025;54(2):521-527
CountryChina
Language:Chinese
Abstract: Bloodstream infection(BSI)is a common infectious complication after hematopoietic stem cell transplantation(HSCT).Due to immunosuppression,the HSCT patients are predisposed to develop BSI,and once complicating drug resistant bacterial infections,the clinical prognosis is extremely poor,which seri-ously affects the long-term survival of the patients.In recent years,with the widespread use of broad-spectrum antibiotics,there have been important changes in the distribution of pathogenic bacteria and antibiotic resist-ance patterns of BSI in HSCT patients.BSI caused by MDR bacteria shows the increasing trend year by year,which has become a very problematic issue in the global anti-infection treatment.Therefore,a timely summary of the latest advance in the epidemiology of bacterial BSI,antibiotic prevention and treatment strategies and management of MDR bacteria infection in HSCT patients has an important significance for optimizing the anti-infective treatment and improving the overall graft effect in the patients.