Mendelian randomization study on hyperthyroidism and systemic lupus erythematosus
10.3969/j.issn.1671-8348.2025.02.026
- VernacularTitle:甲状腺功能亢进症与系统性红斑狼疮的孟德尔随机化研究
- Author:
Shengfei YANG
1
;
Yunda ZHANG
;
Mengling WEI
;
Dongwei LI
Author Information
1. 广东医科大学第一临床医学院,广东湛江 524023;广东省东莞东华医院普外科,广东东莞 523110
- Keywords:
single nucleotide polymorphism;
hyperthyroidism;
systemic lupus erythematosus;
Mende-lian randomization;
autoimmune system disease
- From:
Chongqing Medicine
2025;54(2):441-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between hyperthyroidism and systemic lu-pus erythematosus(SLE).Methods According to the current summary data of genome-wide association studies(GWAS),the screened single nucleotide polymorphism(SNP)was selected as the instrumental varia-bles,hyperthyroidism served as the exposure factor and SLE as the outcome variable,and the Mendelian ran-domization analysis(MR)analysis method was used for conducting the study.Among them,the inverse vari-ance weighting(IVW)was the main MR analysis method,the MR-Egger regression method was used to the test for horizontal pleiotropy,and the sensitivity adopted the leave-one-method test,and the MR results con-ducted the visualized analysis by scatter plot,forest plot and funnel plot.Results Ten valid SNP were screened.In the MR analysis,IVW supported a causal relationship between hyperthyroidism and SLE(OR=1.838,95%CI:1.302-2.593,P<0.001);the MR-egger regression method supported the relationship be-tween hyperthyroidism and SLE(OR=4.070,95%CI:1.961-8.449,P=0.003);in addition,the weighted median method also supported the relationship between hyperthyroidism and SLE(OR=1.685,95%CI:1.238-2.294,P<0.001).Conclusion There appears to be a causal relationship between hyperthyroidism and SLE.
