Efficacy and safety of modified Shenqi Maiwei Dihuang Decoction combined with Buzhong Yiqi Pill in treatment of cold and heat mixed type diabetic foot
10.3969/j.issn.1671-8348.2025.02.017
- VernacularTitle:参芪麦味地黄汤加味联合补中益气丸治疗寒热错杂型糖尿病足的有效性及安全性
- Author:
Yinfeng XIA
1
;
Weiwei CHEN
;
Ping WU
;
Yongsong CHEN
;
Jie LIU
;
Jianxiang PAN
;
Zhiyong CHEN
Author Information
1. 重庆大学附属涪陵医院烧伤整形美容科,重庆 408000
- Keywords:
diabetic foot;
ulcer;
Shenqi Maiwei Dihuang Decoction;
Buzhong Yiqi Pill;
cold and heat mixed type
- From:
Chongqing Medicine
2025;54(2):387-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effects of modified Shenqi Maiwei Dihuang Decoction combined with Buzhong Yiqi Pill and Buzhong Yiqi pill alone in the patients with cold and heat mixed type di-abetic foot.Methods A total of 123 patients with cold and heat mixed type diabetic foot receiving the treat-ment in this hospital from April 2022 to December 2023 were selected and divided into the modified Shenqi Mai-Dihuang Decoction and Buzhong Yiqi Pill group(combined group,60 cases)and Buzhong Yiqi Pill group(monotherapy group,63 cases).The wound healing,mean blood flow amount of foot dorsal artery,blood glu-cose and changes in vascular diameter,inflammatory factors and vascular endothelial growth factor after 2 courses of treatment were compared betweeb the 2 groups.Results The ulcer reduction rate in the combina-tion group was significantly higher than that in the monotherapy group(P=0.001).The fasting blood glu-cose and 2 h postprandial blood glucose after treatment in the combination group all were lower than those in the monotherapy group(P=0.001).The average blood flow of foot dorsal artery after treatment in combina-tion group was higher than that in the monotherapy group,and the difference was statistically significant(P=0.013).There were 34 cases of Wagner grade 3 in the combined group and 33 cases of Wagner grade 3 in the monotherapy subgroup respectively.There was statistically significant difference in the CRP level between the two subgroups(P=0.045).Conclusion Shenqi Maiwei Dihuang Decoction combined with Buzhong Yiqi Pill in treating diabetic foot ulcer is more effective than Buzhong Yiqi Pill alone,moreover the safety is high.
