Influence of chemoradiotherapy mode and number of synchronized chemotherapy cycles on efficacy and prognosis of limited-stage small cell lung cancer
10.3969/j.issn.1671-8348.2025.02.013
- VernacularTitle:放化疗模式及同步化疗周期数对局限期小细胞肺癌疗效及预后的影响
- Author:
Chunyu CHANG
1
;
Yang LIU
;
Jiaoyue QU
;
Gengming WANG
Author Information
1. 蚌埠医科大学第一附属医院肿瘤放疗科,安徽蚌埠 233000
- Keywords:
small cell lung cancer;
limited-stage;
concurrent chemoradiotherapy;
overall survival time;
prognostic factors
- From:
Chongqing Medicine
2025;54(2):360-365,371
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of the radiochemotherapy mode and the number of syn-chronized chemotherapy cycles on the efficacy and overall survival(OS)time of the patients with limited-stage small cell lung cancer(LS-SCLC).Methods The clinical data of 85 patients with LS-SCLC receiving the thoracic radiotherapy(TRT)in the tumor radiotherapy department of this hospital from January 2018 to De-cember 2022 were retrospectively analyzed.The patients were divided into the synchronous chemotherapy group(n=43)and non-synchronous chemotherapy group(n=42)according to different radiochemotherapy modes.The OS and progress free survival(PFS)time was compared between the two groups,and the related prognostic influencing factors of LS-SCLC were analyzed.Results The last follow-up date was November 1,2023,and the median follow-up time in all groups was 39.6 months.The median OS time of the synchronous chemotherapy group and non-synchronous chemotherapy group was 30.6 months and 18.6 months respective-ly,and the difference was statistically significant(P<0.05).The median OS time of 1 cycle and 2 cycles in the synchronous chemotherapy group was 25.5 months and 33.6 months,and the difference was not statisti-cally significant(P>0.05).The Cox multivariate regression analysis results showed that the age,clinical stage and prophylactic cranial irradiation(PCI)were the independent prognostic influencing factors in the pa-tients with LS-SCLC.Conclusion The number of synchronized chemotherapy cycles has no significant influ-ence on the prognosis of LS-SCLC.
