Influencing factors of infection occurrence after using tofacitinib in patients with rheumatoid arthritis
10.3969/j.issn.1671-8348.2025.02.010
- VernacularTitle:类风湿关节炎患者使用托法替布后发生感染的影响因素
- Author:
Min HUANG
1
;
Guoxiang YI
;
Chengyin LI
;
Yanping LI
Author Information
1. 湖南中医药大学,长沙 410208;重庆市中医院,重庆 400021
- Keywords:
tofacitinib;
rheumatoid arthritis;
infection;
risk factor
- From:
Chongqing Medicine
2025;54(2):340-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the related influencing factors of the infection oc-currence after using tofacitinib in the patients with rheumatoid arthritis.Methods The case data of 211 pa-tients with rheumatoid arthritis treated by tofacitinib in the rheumatology and immunology department of Chongqing Municipal Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were col-lected.The patients were grouped according to whether infection occurred or not.After single factor test on gender,age,Chinese medicine syndromes,time of taking Chinese medicine,lung system diseases and lympho-cyte count,then the factors with statistically significant differences were included in the Logistic regression a-nalysis.Results Spleen deficiency and dampness syndrome,taking traditional Chinese medicine time 1-4 weeks,and>4-<8 weeks were the protective factors for the infection occurrence after using tofacitinib in rheumatoid arthritis(OR=0.427,95%CI:0.184-0.988,P<0.05;OR=0.233,95%CI:0.093-0.580,P<0.05;OR=0.328,95%CI:0.135-0.799,P<0.05),complicating pulmonary interstitial lesions and bronchi-ectasis were the risk factors for infection occurrence after using tofactitinib(OR=3.000,95%CI:1.306-6.894,P<0.05;OR=16.615,95%CI:1.782-154.945,P<0.05).Conclusion The risk of infection occur-rence after using tofacitinib in the patients with rheumatoid arthritis is closely correlated with Chinese medi-cine syndromes,time of taking Chinese medicine and lung system diseases.
