Correlation between nutritional risk and frequent acute exacerbation of COPD
10.3969/j.issn.1671-8348.2025.02.009
- VernacularTitle:营养风险与慢性阻塞性肺疾病频繁急性加重的关系研究
- Author:
Haiyue LIU
1
;
Feng LI
;
Yihua LIN
;
Zuheng LIU
Author Information
1. 厦门大学附属第一医院检验科/厦门市基因检测重点实验室,福建厦门 361000;厦门大学医学院,福建厦门 361000
- Keywords:
COPD;
frequent exacerbation risks;
NRS-2002 nutritional risk screening;
neutrophil to al-bumin ratio;
platelet to lymphocyte ratio
- From:
Chongqing Medicine
2025;54(2):335-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the nutritional risk and the risk of frequent acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods The patients with acute exac-erbation of COPD(AECOPD)hospitalized in the respiratory and critical care medicine department of the First Affiliated Hospital of Xiamen University were collected and divided into the frequent acute exacerbation risk group(FE)and non-frequent exacerbation risk group(NE).The nutritional risk was evaluated by the Nutri-tional Risk Screening Scale-2002(NRS-2002)(1-2 points as no nutritional risk,3-7 points as nutritional risk).The relationship between the two was analyzed by statistics and logistic regression.Results The FE group had longer hospital stay(P<0.01)and a higher proportion of hypertension(P<0.01).In terms of in-flammatory indicators,the neutrophil to albumin ratio(P<0.01)and platelet to lymphocyte ratio(P<0.05)in the FE group were significantly increased.In the aspect of nutritional status,the NRS-2002 score in the FE group showed a higher proportion of nutritional risk population(P<0.01),meanwhile the total protein(P<0.01)and albumin(P<0.05)levels were significantly decreased.After adjusting the confounding factors such as gender,hospitalization duration,inflammatory markers and history of underlying diseases,the full fac-tor logistic regression analysis revealed that the frequent acute exacerbation risk in COPD patients with nutri-tional risk was significantly higher that in the patients with no nutritional risk[odds ratio(OR)=2.948;95%confidence interval(95%CI):1.112-7.816;P<0.05].Conclusion The COPD patients with nutritional risk in NRS-2002 scores exhibit a significantly increased risk of frequent acute exacerbation compared to those without nutritional risk.
