Research progress in pathological mechanism and biomarkers of sepsis-associated acute kidney injury
10.3969/j.issn.1671-8348.2025.01.042
- VernacularTitle:脓毒症相关急性肾损伤病理机制及生物标志物的研究进展
- Author:
Yang YANG
1
;
Wen TANG
;
Junchuan GUO
;
Dong XIAO
Author Information
1. 新疆医学科大学研究生学院,乌鲁木齐 830000
- Keywords:
sepsis;
acute kidney injury;
biomarkers;
pathophysiology;
sepsis-associated acute kidney in-jury
- From:
Chongqing Medicine
2025;54(1):231-236
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is one of the main causes leading to acute kidney injury(AKI)occurrence in critically ill patients,and about 40％of the patients with sepsis develop AKI.The pathophysiology of sepsis-associated acute kidney injury(SA-AKI)is complex,possibly involving the many mechanisms such as hemodynamics,in-flammation and immunity.The patients with SA-AKI have a poorer prognosis,longer hospital stay and more complications compared to those without AKI.However,there is still a lack of effective means for early identi-fication,prevention and treatment of SA-AKI.Studies have found that new biomarkers may diagnose SA-AKI more sensitively.This paper discusses the latest progress in SA-AKI pathophysiology,summarizes the func-tional,traumatic and stress markers in diagnosing AKI in recent years,their accuracy and limitation for predic-ting AKI occurrence,and investigates their potential for the assisted diagnosis and treatment guidance in order to identify the patients with SA-AKI as early as possible and promote the individualized treatment to improve the prognosis of the patients.
