Research progress on small intestinal bacterial overgrowth and type 1 diabetes

VernacularTitle:小肠细菌过度生长与1型糖尿病的研究进展
Author: Tingyi ZHU ¹ ; Yangyang LI ; Yu LIU
Author Information

1. 南京医科大学附属逸夫医院内分泌科,南京 211112
Keywords: type 1 diabetes; small intestinal bacterial overgrowth; mechanism; treatment
From: Chongqing Medicine 2025;54(1):207-212
CountryChina
Language:Chinese
Abstract: Type 1 diabetes mellitus(T1DM)is an autoimmune diabetes caused by the destruction of βcells and insulin absolute insufficiency,which is influenced by a combination of genetic and environmental fac-tors.In recent years,gut microbiota as an important part of regulating host disease and health status has re-ceived the extensive attention.Small intestinal bacterial overgrowth(SIBO)is a type of intestinal microbial dysbiosis that is associated with T1DM.The presence of SIBO may exacerbate the development of T1DM,which is closely associated with the high incidence of SIBO,however,the causal relationship between SIBO and T1DM and its specific mechanism of action are not well elucidated.This article reviews the relationship and interaction between SIBO and T1DM,and its potential mechanisms and interventional measures,which may help to discover the new therapeutic targets and develop the new treatment regimens for T1DM.