Analysis on influencing factors of feeding intolerance in patients with severe traumatic brain injury
10.3969/j.issn.1671-8348.2025.01.032
- VernacularTitle:重型颅脑损伤患者喂养不耐受的影响因素分析
- Author:
Haiju LI
1
;
Longti LI
;
Na WANG
;
Junlin XIA
Author Information
1. 十堰市太和医院/湖北医药学院附属医院神经重症医学科,湖北十堰 442000
- Keywords:
severe traumatic brain injury;
enteral nutrition;
feeding intolerance;
influencing factors
- From:
Chongqing Medicine
2025;54(1):172-175,180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors of feeding intolerance in the patients with se-vere traumatic brain injury(STBI).Methods The clinical data in 96 patients with STBI in this hospital from January 2023 to December 2023 were retrospectively analyzed.The patients were divided into the tolerance group and non-tolerance group according to whether the intolerance developed during the feeding process.The general condiction,laboratory detection,treatment measures and enteral nutrition implementation condition were recorded.The multivariate logistic regression was used to analyze the influencing factors of feeding intol-erance in STBI patients.Results Among 96 patients,43 cases(44.79％)developed the feeding intolerance.The results of univariate analysis showed that GCS score,blood glucose,serum albumin,starting time of en-teral nutrition,sedative drugs use,mechanical ventilation,antacids use,combined use of antibiotics,vasoactive drugs use,mild hypothermia therapy and prone position ventilation were related with the feeding intolerance in STBI patients.The multivariate logistic regression analysis showed that combined use of antibiotics(OR=43.628,P=0.002),use of vasoactive drugs(OR=140.211,P=0.004),delayed initiation of enteral nutrition(OR=44.529,P=0.009),mild hypothermia treatment(OR=439.599,P=0.001)and prone position venti-lation(OR=288.702,P=0.014)were the independent influencing factors of feeding intolerance in STBI pa-tients.Conclusion STBI patients are prone to develop the feeding intolerance.If there is no contraindication,the enteral nutrition should be initiated as early as possible,and the personalized prevention and treatment measures aiming at various influencing factors should be formulated.
