Correlation between serum adipsin and coronary artery vulnerable plaque in patients with coronary heart disease complicating diabetes
10.3969/j.issn.1671-8348.2025.01.029
- VernacularTitle:血清adipsin与冠心病合并糖尿病患者冠状动脉易损斑块的相关性
- Author:
Na ZHANG
1
;
Meili ZHAO
Author Information
1. 内蒙古科技大学包头医学院,内蒙古包头 014040;乌兰察布市中心医院心血管内科,内蒙古乌兰察布 012000
- Keywords:
adipsin;
coronary heart disease;
diabetes mellitus;
vulnerable plaque
- From:
Chongqing Medicine
2025;54(1):158-162,167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between serum adipsin and vulnerable plaques.Methods A total of 80 patients with coronary heart disease complicating diabetes mellitus due to chest pain hospitalized in the cardiovascular medicine department of Ulanqab Municipal Central Hospital from January 2023 to January 2024 were selected as the study subjects and conducted the coronary angiography and optical coherence tomo-graphy(OCT).The serum adipsin level was detected.The relationship between serum adipsin and thin fibrous cap atherosclerotic plaque(TCFA)was analyzed by binary logistic regression.The receiver operating charac-teristic(ROC)curve was used to analyze the diagnostic efficiency of adipsin in predicting TCFA.Results The levels of creatinine,low-density lipoprotein-cholesterol(LDL-C)and serum adipsin in the TCFA group were significantly higher than those in the non-TCFA group,and the difference was statistically significant(P＜0.05);the proportions of TCFA and acute myocardial infarction in the high adipsin group were higher than those in the low adipsin group,and the difference was statistically significant(P＜0.05).The binary logistic regression analysis results showed that creatinine,LDL-C and serum adipsin all were the independent predic-tive factors of TCFA(P＜0.05).The ROC curve showed that AUC of serum adipsin in predicting TCFA was 0.702(95％CI:0.589-0.815,P=0.002),the cut-off value was 2.845 ng/mL,the sensitivity was 0.897 and the specificity was 0.585.Conclusion As an independent predictive factor of TCFA,serum adipsin is closely related to the occurrence and development of vulnerable plaques in the patients with coronary heart disease complicating diabetes.
