Status quo of pathogenesis and treatment of HIV-associated lymphoma
10.3969/j.issn.1671-8348.2025.01.001
- VernacularTitle:HIV感染相关淋巴瘤的发病机制及治疗现状
- Author:
Yi LIU
1
;
Yao LIU
Author Information
1. 重庆大学医学院,重庆 400030
- Keywords:
HIV-associated lymphoma;
pathogenesis;
chemotherapy;
targeted therapy;
hematopoietic stem cell transplantation
- From:
Chongqing Medicine
2025;54(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
HIV infection-associated lymphoma(HAL)is a lymphoma that develops after HIV infection and one of commonest malignant tumors in the AIDS patients.The pathogenesis of HAL involves multiple factors,including the direct effects of HIV,immunodepletion and immune escape,chronic activation of B cells and co-infection of oncogenic viruses.The treatment regimens for HAL include chemotherapy,monoclonal an-tibody therapy and stem cell transplantation.The first-line treatment regimens are different according to dif-ferent subtypes of HLA.For recurrent or refractory HAL,the second line salvage chemotherapy or transplan-tation may be considered.Although the treatment of HAL still remains challenging,but new therapeutic methods offer the hope for future research and treatment.
