Progress in medical application of mussel adhesive protein

VernacularTitle:贻贝黏蛋白的医疗应用进展
Author: Yong ZOU ¹ ; Xingkai WANG ; Bolin AN ; Yudong ZHAO
Author Information

1. 华润医药商业集团医疗器械有限公司,北京 100070
Keywords: mussel adhesive protein; dopa; synthetic biological technology; review
From: Chongqing Medicine 2024;53(24):3810-3814
CountryChina
Language:Chinese
Abstract: Mussel mucin(MAP),due to its rich lysine,dopamine and hydrophobic groups,can be tar-geted for various indications applied to current skin and mucosal tissues and shows great potential in the medi-cal field.This article outlines the structure of these proteins,the recent advancement of protein expression and biomanufacturing using various synthetic biology tools,and the status of relevant clinical research.This paper deeply explores the structure of these proteins,application of synthetic biology tools in their expression and biofabrication and the latest progress in clinical research,and analyzes the related policy in the medical indus-try from the angles of the products,classification,registration and industrial standard in order to understand its development status quo and provide reference for extending the clinical application.