Study advances in effects of ketamine and esketamine on hemodynamics in surgical patients
10.3969/j.issn.1671-8348.2024.24.022
- VernacularTitle:氯胺酮和艾司氯胺酮对手术患者血流动力学影响的研究进展
- Author:
Shu WANG
1
;
Qiao GUO
;
Yuanjing CHEN
;
Guangyou DUAN
;
He HUANG
Author Information
1. 重庆医科大学附属第二医院麻醉科,重庆 400010
- Keywords:
ketamine;
esketamine;
hemodynamics;
anesthetic drugs;
review
- From:
Chongqing Medicine
2024;53(24):3800-3805
- CountryChina
- Language:Chinese
-
Abstract:
In clinical surgery,various anesthetic drugs produce different effects on the blood circulation of patients.For example,propofol and inhaled anesthetics may lead to dose-related cardiovascular depression,meanwhile which is accompanied by sympathetic nerve tensile decline,vascular resistance decrease and is easy to induce postoperative hypotension.Ketamine can activate the sympathetic nervous system leading to release catecholamines and inhibit the vagus nerve,thus which is clinically manifested as increased blood pressure,in-creased heart rate and other cardiovascular excitation characteristics.As the dextroisomer-isomer of ketamine,esketamine(S-ketamine)not only retains the properties of ketamine,but also has relatively few side effects.Currently,it has been used in clinical anesthesia induction and maintenance,analgesia and treatment of refrac-tory depression.This paper provides a comprehensive overview of the effects of ketamine and S-ketamine on the hemodynamics of general anesthesia.
