Research progress on macrophage polarization in cancer bone metastasis
10.3969/j.issn.1671-8348.2024.24.021
- VernacularTitle:巨噬细胞极化在癌症骨转移中的研究进展
- Author:
Xiang LI
1
;
Zhenyu WEN
;
Qiping HUANG
;
Yi YANG
;
Honghan WU
;
Qingde WA
Author Information
1. 遵义医科大学第二附属医院骨科,贵州遵义 563000
- Keywords:
bone metastasis;
macrophage polarization;
M1 macrophages;
M2 macrophages;
tumor mi-croenvironment
- From:
Chongqing Medicine
2024;53(24):3793-3799
- CountryChina
- Language:Chinese
-
Abstract:
Bone metastasis is a common complication of many advanced cancers,especially prostate cancer(85％),breast cancer(70％)and lung cancer(40％),which severely affects the quality of life of the pa-tients and increases its death risk.Macrophages are the essential immune cells in the human body that play a crucial role in the tumor microenvironment(TME),including phagocytosis or removal of cell debris,damaged or apoptotic cells.The phenotypic and functional transition of macrophages is a dynamic process.Under vari-ous stimulation conditions in TME,they can be transformed into two major subpopulations:M1 and M2.In TME,M1 macrophages exert anti-tumor effects and contribute to tumor immunity.M2 macrophages display a robust immunosuppressive phenotype,aiding in tumor cell proliferation and thereby promoting the occurrence of bone metastasis.This article reviews the interaction between macrophages and TME,and explores the role of macrophage polarization in bone metastasis of common cancers such as prostate cancer,breast cancer and lung cancer,and the influence in the occurrence and development of tumors.
