Study on value of biological markers in diagnosis of Kawasaki disease in children
10.3969/j.issn.1671-8348.2024.24.012
- VernacularTitle:生物学标志物对儿童川崎病诊断价值的研究
- Author:
Aimin WU
1
;
Yongming SHEN
Author Information
1. 天津市儿童医院/天津大学儿童医院检验科,天津 300134
- Keywords:
Kawasaki disease;
markers;
C reactive protein;
ROC curve;
children
- From:
Chongqing Medicine
2024;53(24):3752-3755
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen the biological markers in the assisted detection of childhood Kawasaki disease(KD).Methods A total of 208 children inpatients initially diagnosed as KD in this hospital from Janu-ary 2022 to December 2023 were selected as the KD group,and 208 healthy children undergoing physical ex-amination in this hospital were selected as the control group.Serum C reactive protein(CRP),white blood cells(WBC),platelets(PLT),erythrocyte sedimentation rate(ESR),procalcitonin(PCT),antistreptolysin O(ASO),interleukin-6(IL-6),immunoglobulin IgG,IgA,IgM,IgE,complement C3,C4 and serum ferritin(Fer)in the two groups were detected,and the receiver operating characteristic(ROC)curve was used to e-valuate the value of the various biological indexes for diagnosing KD.Results The levels of CRP,WBC,PLT,ESR,IgM,complement C4,Fer,PCT and IL-6 in the KD group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The ROC curve showed that the areas under the curves(AUC)of CRP,WBC,ESR,PCT and IL-6 all were＞0.9,in which,AUC of CRP was 1.000,when 2.25 ng/L was the cut-off value,the sensitivity and specificity were 100.0％.AUC of IL-6 was 0.998,when 6.595 mg/L was the cut-off value,the sensitivity was 97.1％and the specificity was 99.0％.AUC of ESR was 0.987,when 18.50 mm/h was the cut-off value,the sensitivity was 96.0％and the specificity was 99.0％.Conclusion CRP,IL-6 and ESR have the higher diagnostic value for KD.
