Research progress on sleep disorders affecting mucosa healing mechanism after oral ulcer
10.3969/j.issn.1671-8348.2024.23.022
- VernacularTitle:睡眠障碍影响口腔溃疡后黏膜愈合机制的研究进展
- Author:
Qi HUANG
1
;
Kehao LIU
;
Ziyu HUANG
;
Sheng YANG
;
Yuzhou LI
Author Information
1. 重庆医科大学口腔医学院,重庆 401147
- Keywords:
sleep disorders;
insomnia;
oral ulcer;
mucosal regeneration;
mucosal healing;
review
- From:
Chongqing Medicine
2024;53(23):3645-3650
- CountryChina
- Language:Chinese
-
Abstract:
Oral ulcers refers to the disruption occurrence of mucosal epithelial integrity,its occurrence and development are affected by a variety of factors such as systemic diseases,genetics,immunity and systemic subhealth state;sleep is closely related to human health,and long-term sleep disturbance can lead to endocrine disorders,immune disorders,and metabolic diseases.Epidemiologic studies find that sleep quality is closely re-lated to mucosal healing,and sleep disorders may be a potential risk factor for impaired mucosal healing.The animal experiments verify that sleep deprivation exacerbates oral ulcer symptoms and delays the oral ulcer healing in rats,but the exact cellular and molecular mechanisms are unclear.This paper reviews the mecha-nisms of sleep disorders in affecting mucous membrane healing after oral ulcer in order to provide a theoretical basis for basic research and treatment of mucosal healing and soft tissue regeneration.
