Clinical value of GP73,IL-2R and miR-21 in predicting significant hepatic fibrosis in patients with chronic hepatitis B
10.3969/j.issn.1671-8348.2024.23.010
- VernacularTitle:GP73、IL-2R、miR-21预测慢性乙肝患者显著肝纤维化的临床价值
- Author:
Shumei LI
1
;
Bing LIU
;
Renwei LIU
;
Jie YANG
Author Information
1. 西南医科大学临床医学院,四川泸州 646000;四川绵阳四0四医院/绵阳市第一人民医院感染科,四川绵阳 621000
- Keywords:
chronic hepatitis B;
Golgi protein 73;
interleukin-2 receptor;
microRNA-21;
significant liver fibrosis;
clinical value
- From:
Chongqing Medicine
2024;53(23):3575-3580
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum Golgi transmembrane protein 73(GP73)and interleu-kin-2 receptor(IL-2R)and microribonucleic acid-21(miR-21)in predicting significant hepatic fibrosis in the patients with chronic hepatitis B(CHB).Methods A total of 106 patients with CHB admitted and treated in Mianyang 404 Hospital from January 2020 to December 2022 were collected as the study subjects.According to the classification of liver fibrosis degree and clinical data,the stage S0-S1 served as the mild liver fibrosis group(n=80)and the stage S2-S4 as the significant liver fibrosis group(n=26).The correlation between serum GP73,IL-2R and miR-21 with significant liver fibrosis was analyzed.The significant liver fibrosis occur-rence served as the dependent variable,the sex,age,BMI,serum GP73,IL-2R,miR-21,HBV DNA load and an-ti-HBS were included to conduct the stepwise Logistic regression analysis.The receiver operating characteris-tic(ROC)curve was adopted to analyze the diagnostic efficiency.Results Compared with the mild liver fibro-sis group,the serum GP73,IL-2R and miR-21 levels in the significant liver fibrosis group were higher,and the difference was statistically significant(P＜0.05).The serum GP73(r=0.472),IL-2R(r=0.625)and miR-21(r=0.663)levels were positively correlated with the significant liver fibrosis,and the difference was statis-tically significant(P＜0.001).The multivariate analysis results showed that the serum GP73 and IL-2R were the independent influencing factors of significant liver fibrosis in the patients with CHB.Based on GP73≥150.75 ng/mL and IL-2R≥698.6 μg/mL,which could predict the probability of significant liver fibrosis oc-currence in the patients with CHB.The area under the curve(AUC)of the three combination for diagnosing significant liver fibrosis was the greatest(0.976),the sensitivity(96.2％)and specificity(90.0％)were the highest.Conclusion The serum GP73,IL-2R and miR-21 combination has good predictive value for significant liver fibrosis.
