Research progress of exosome miRNA and exosome cell-free therapy in myocardial infarction
10.3969/j.issn.1671-8348.2024.10.021
- VernacularTitle:心肌梗死外泌体miRNA及外泌体无细胞疗法的研究进展
- Author:
Xinyu WU
1
;
Jingru LI
;
Luqiao WANG
Author Information
1. 昆明医科大学第一附属医院心血管内科,昆明 650032
- Keywords:
exosomes;
miRNA;
myocardial infarction;
biomarkers;
regulation mechanism;
review
- From:
Chongqing Medicine
2024;53(10):1557-1562
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction(MI)is an irreversible myocardial injury caused by continuous ische-mia and hypoxia of coronary arteries,which seriously threatens people's life and health.Exosomes are nanoscale bilayer lipid vesicles released into the surrounding body fluids after the fusion of multivesicular bodies and plasma membranes.As an important bioactive molecule contained in exosomes,miRNAs regulate the pathological mechanism of MI by changing various biological pathways.Exosomes have the advantages of high stability,low toxicity,and controllable dose.Exosome-based cell-free therapy loaded with miRNA has e-merged.This article reviewed the diagnostic and prognostic value of exosome miRNA in MI,and discussed the application prospects and limitations of exosomal cell-free therapy.
