Research advances in cholesterol metabolism based on the role of tumor immunomodulation
10.13406/j.cnki.cyxb.003924
- VernacularTitle:基于肿瘤免疫调控作用的胆固醇代谢研究进展
- Author:
Jiayu ZHANG
1
;
Xinting ZHU
;
Leng HAN
;
Zhengyun ZHANG
;
Xiuyan HUANG
;
Jing ZHANG
;
Jie LI
;
Cheng GUO
;
Quanjun YANG
Author Information
1. 上海交通大学医学院附属松江医院药剂科,上海 201600
- Keywords:
cholesterol;
macrophages;
CD8+T cells;
CD4+T cells;
proprotein convertase subtilisin kexin type 9
- From:
Journal of Chongqing Medical University
2025;50(11):1500-1505
- CountryChina
- Language:Chinese
-
Abstract:
Cholesterol,as an important component of cell membranes,plays a multifaceted role in mediating tumor immunomodulation and drug intervention.In case of cholesterol metabolic imbalance,the accumulation of cholesterol metabolic intermediates,the changes in concentrations,and the regulation of related signaling pathways can affect tumor immunity by promoting inflammation and inhibiting immune cell function.Preclinical and clinical studies have shown that controlling cholesterol metabolism can inhibit tumor growth,re-shape body immune regulation,and enhance antitumor immunity.A deep understanding of the association between immune cells and cholesterol metabolic pathways in the tumor microenvironment can help to develop novel drugs targeting cholesterol metabolism.This article reviews the multifaceted role of cholesterol and its derived metabolites in the tumor microenvironment by regulating various types of immune cells such as myeloid-derived suppressor cells,tumor-associated macrophages,dendritic cells,and T-lymphocytes,as well as the characteristics of tumor immunomodulation mediated by cholesterol metabolism and the advances in pharmaceutical re-search on improving the immune function of the body by intervening against cholesterol,in order to further provide new ideas and a thera-peutic basis for cholesterol modulation and intervention in tumor im-munotherapy.
