Recent advances in the role of lipid rafts in the development and progression of diabetes
10.13406/j.cnki.cyxb.003846
- VernacularTitle:脂筏与糖尿病发生发展的最新研究进展
- Author:
Lingkun YANG
1
;
Jiawang JIANG
;
Mengyu ZHANG
;
Xiyue GAO
;
Shuhong PENG
Author Information
1. 江西中医药大学中医基础理论分化发展研究中心/江西省中医病因生物学重点实验室,南昌 330004
- Keywords:
diabetes;
lipid rafts;
pancreas;
liver;
adipose tissue
- From:
Journal of Chongqing Medical University
2025;50(11):1487-1492
- CountryChina
- Language:Chinese
-
Abstract:
Lipid rafts are microdomains in the cell membrane that are involved in cell signal transduction,metabolism,and intercellu-lar interactions.In recent years,studies have shown that lipid rafts play an important role in the pathogenesis of diabetes.Cholesterol and sphingolipids are the main lipid components in lipid rafts,and the protein components in lipid rafts include caveolin,flotillin,pal-mitoylated proteins,and glycosylphosphatidylinositol-anchored proteins.Changes in these components affect the structure and function of lipid rafts,which in turn may affect insulin signal transduction,leading to the occurrence of diabetes-related diseases.Lipid rafts are closely related to the occurrence and development of diabetes in different tissues.Pancreatic lipid rafts are closely related to insulin se-cretion,and their structural changes affect insulin synthesis and release.Changes in lipid rafts in adipose tissue are related to insulin resistance and disorders of glycolipid metabolism.Changes in lipid rafts in the liver can affect gluconeogenesis and glycogen synthesis.Lipid rafts in the kidney play a regulatory role in the progression of diabetic nephropathy.This article aims to provide a comprehensive overview of the role of lipid rafts in the pathogenesis of diabetes,offering insights into the identification of new targets for the prevention and treatment of diabetes in the future,as well as presenting a new perspective for the development of therapeutic agents for diabetes.
