Research advances in traditional Chinese medicine for the prevention and treatment of ischemic stroke by regulating B-cell lymphoma-2 family proteins through anti-apoptotic mechanisms
10.13406/j.cnki.cyxb.003880
- VernacularTitle:中医药调控Bcl-2家族蛋白抗细胞凋亡防治缺血性脑卒中的研究进展
- Author:
Haiqian ZHANG
1
;
Yanyan ZHOU
;
Jian ZHANG
;
Quan LI
Author Information
1. 黑龙江中医药大学基础医学院,哈尔滨 150040
- Keywords:
ischemic stroke;
B-cell lymphoma-2 family proteins;
cell apoptosis;
monomers of Chinese herbs;
compound traditional Chinese medicine prescriptions
- From:
Journal of Chongqing Medical University
2025;50(11):1465-1471
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke(IS)is a common cerebrovascular disease,and its pathogenesis is closely associated with brain cell death due to insufficiency of cerebral blood supply.In recent years,cell apoptosis has become a research hotspot in the pathogenesis of IS.The B-cell lymphoma-2(Bcl-2)family proteins associated with cell apoptosis are the key regulators for apoptosis and are mainly in-volved in the intrinsic apoptotic pathway,and they regulate cell apoptosis by mediating the two pathways of mitochondrial membrane permeability and Ca2? overload,thereby delaying the progression of IS.Starting from the anti-apoptotic mechanisms of Bcl-2 family proteins,this article summarizes the research advances in traditional Chinese medicine for the prevention and treatment of IS by regu-lating B-cell lymphoma-2 family proteins from the aspects of the structural features of Bcl-2 family proteins,their anti-apoptotic role in IS,and traditional Chinese medicine regulation.The results show that the anti-apoptotic strategies in IS mainly focus on the regula-tion of Bcl-2 and Bax proteins,and monomers of Chinese herbs,traditional Chinese medicine extracts,and compound traditional Chi-nese medicine prescriptions were used for treatment,which further confirms the great potential of traditional Chinese medicine in the prevention and treatment of IS and provides a theoretical basis for future experimental research and clinical treatment.
