Research advances in traditional Chinese medicine for treating ischemic stroke by regulating the hypoxia-inducible factor 1α signaling pathway
10.13406/j.cnki.cyxb.003909
- VernacularTitle:中药调控HIF-1α信号通路治疗缺血性脑卒中的研究进展
- Author:
Lishuang YAN
1
;
Jian ZHANG
;
Weidong WU
;
Yanyan ZHOU
Author Information
1. 黑龙江中医药大学基础医学院/黑龙江省中医基础理论研究重点实验室,哈尔滨 150040
- Keywords:
hypoxia-inducible factor 1α;
ischemic stroke;
angiogenesis;
energy metabolism;
blood-brain barrier
- From:
Journal of Chongqing Medical University
2025;50(11):1457-1464
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke(IS)is a disease caused by insufficient blood and oxygen supply to cerebral vessels,with the main clinical manifestations of hemiplegia,sensory disturbance,aphasia,and ataxia.Studies have shown that hypoxia-inducible factor 1α(HIF-1α),as the core regulatory element of oxygen homeostasis,can be rapidly activated under hypoxia/ischemia conditions,thereby playing an important role in the pathophysiology of IS.In recent years,more and more articles have shown that the active components of tradi-tional Chinese medicine,Chinese patent drugs,and compound traditional Chinese medicine prescriptions can effectively regulate the HIF-1α-related signaling pathway in the treatment of IS,but there is no systematic summary on regulation of the HIF-1α signaling pathway in the treatment of IS.Therefore,this article mainly summarizes the structure and physiological activity of HIF-1α and its mechanisms of action in IS and reviews related studies on Chinese medicine monomers and compound prescriptions in the treatment of IS in the past five years in China and globally.It is pointed out that the Chinese medicine monomers and compound prescriptions can repair brain tissue,alleviate brain tissue damage,and exert a therapeutic effect on IS by regulating the HIF-1α pathway to promote an-giogenesis,inhibit neuroinflammation and oxidative stress,promote energy metabolism,and repair blood-brain barrier damage.
