Current research status of aquaporin 5 in regulating programmed cell death in Sj?gren's syndrome
10.13406/j.cnki.cyxb.003835
- VernacularTitle:AQP5调控细胞程序性死亡在干燥综合征中的研究现状
- Author:
Youxia WANG
1
;
Cuijuan LI
;
Zhendong GONG
;
Rui HU
;
Yong HU
;
Xiyan ZHANG
;
Qiliu WANG
Author Information
1. 陕西中医药大学基础医学院,咸阳 712046
- Keywords:
aquaporin 5;
Sj?gren's syndrome;
programmed cell death
- From:
Journal of Chongqing Medical University
2025;50(10):1385-1391
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin 5(AQP5)is a specific protein that can significantly increase the water permeability of cell membrane,partici-pate in the process of water secretion and absorption,maintain the balance of water molecules inside and outside the cell,and transport water across the membrane.Programmed cell death(PCD)is closely associated with the development and progression of Sj?gren's syn-drome(SS).AQP5 may influence the development and progression of SS by regulating the PCD mechanism.This article reviews the mo-lecular mechanisms of AQP5 in regulating the apoptosis,pyroptosis,autophagy,and ferroptosis of cells in recent years and discusses the potential influence of AQP5 on SS,in order to provide a theoretical basis for the clinical prevention and treatment of SS.
