Research advances in the mechanism of clemastine regulating oligodendrocytes and remyelination
10.13406/j.cnki.cyxb.003928
- VernacularTitle:氯马斯汀调控少突胶质细胞髓鞘修复的机制研究进展
- Author:
Xiaojuan ZHANG
1
;
Yao CHEN
;
Chao ZHANG
;
Binbin TANG
;
Xianjun CHEN
Author Information
1. 四川省第二中医医院药学部,成都 610031
- Keywords:
clemastine;
oligodendrocyte;
myelin sheath repair;
nervous system diseases
- From:
Journal of Chongqing Medical University
2025;50(10):1323-1328
- CountryChina
- Language:Chinese
-
Abstract:
Oligodendrocytes(OLs)play a crucial role in the central nervous system,and the myelin sheath formed by them is essential for maintaining the normal function of the nervous system.Damage to the myelin sheath can trigger various nervous system diseases,which seriously affect the quality of life of patients.Clemastine,a traditional antihistamine,has shown certain potential in"repurposing old drugs"in recent years and can promote the repair of myelin sheath.This article summarizes the role of clemastine in regulating the differentiation,maturation,senescence,and apoptosis of OLs at multiple levels by acting on receptors on the OL membrane and regulat-ing the key signaling pathways in cells and epigenetic modifications in the nucleus.A deeper understanding of the mechanism of action of clemastine in OLs can help to provide new targets and new approaches for drug treatment of myelin-degenerative diseases.
