The role of H-type vessels as a mediator of subchondral bone remodeling and cartilage degeneration in the pathogenesis of knee osteoarthritis
10.13406/j.cnki.cyxb.003896
- VernacularTitle:H型血管作为软骨下骨重构与软骨退变媒介在膝骨关节炎发病机制中的作用
- Author:
Zifeng YE
1
;
Yiwei YUAN
;
Liguo QIU
;
Gaoyan KUANG
;
Min LU
Author Information
1. 湖南中医药大学第一中医临床医学院,长沙 410208
- Keywords:
knee osteoarthritis;
subchondral bone;
H-type vessel;
cartilage degeneration
- From:
Journal of Chongqing Medical University
2025;50(9):1247-1252
- CountryChina
- Language:Chinese
-
Abstract:
There is a close relationship between subchondral bone remodeling and angiogenesis in knee osteoarthritis(KOA).Type H vessels,a newly identified subtype of bone vasculature,play a pivotal role in linking angiogenesis with osteogenesis by mediating signals through various cytokines,thereby regulating bone growth and homeostasis.During KOA development,mechanical loads and factors like transforming growth factor-β1(TGF-β1),platelet-derived growth factor-BB(PDGF-BB),vascular endothelial growth factor(VEGF)cause abnormal H-type vessel growth in subchondral bone and cartilage.This suggests that H-type vessel regulation might be a potential KOA treatment mechanism.This article explores the role of H-type vessels in subchondral bone remodeling and cartilage degeneration and the factors driving their abnormal growth,which provides a theoretical basis for further research and high-lights the potential of targeting H-type vessels for KOA treatment.
