Lactate dehydrogenase:a potential regulatory molecule in preeclampsia

VernacularTitle:乳酸脱氢酶:子痫前期的潜在调控因子
Author: Xiaoyue ZHANG ¹ ; Zhenzhen LIU ; Jiangnan PEI ; Weirong GU
Author Information

1. 复旦大学附属妇产科医院产科,上海 200090
Keywords: lactate dehydrogenase; preeclampsia; pathogenesis
From: Journal of Chongqing Medical University 2025;50(9):1242-1246
CountryChina
Language:Chinese
Abstract: Preeclampsia(PE)is a severe pregnancy complication that poses significant risks to maternal and fetal health,and its pathogenesis remains unclear.Recent studies have shown that lactate dehydrogenase(LDH),a key enzyme in glycolysis,plays a piv-otal role in the development and progression of PE.This article reviews the abnormal changes in the levels of LDH and its isozymes in serum and placental tissue and their impact on the pathogenesis of PE and analyzes the molecular mechanisms by which LDH subunits contribute to placental dysfunction through multiple pathways including hypoxia,inflammation,autophagy dysregulation,and cellular damage.In addition,this article discusses the role of lactate,a metabolic product of LDH activity,in the pathogenesis of PE.LDH can be used as a potential biomarker for PE,and the regulation of non-metabolic functions and metabolic reprogramming mediated by LDH provide new targets for the prevention and treatment of PE.