Alterations of adenosine in tumor microenvironment and its impact on tumor treatment
10.13406/j.cnki.cyxb.003776
- VernacularTitle:肿瘤微环境中腺苷的改变及其对肿瘤治疗的影响
- Author:
Lingjie JING
1
;
Leng HAN
;
Dingyuan BAI
;
Yuxuan ZHOU
;
Xinting ZHU
;
Jiayu ZHANG
;
Cheng GUO
;
Quanjun YANG
Author Information
1. 上海交通大学医学院附属第六人民医院,上海 200233
- Keywords:
adenosine;
tumor microenvironment;
tumor treatment;
targeted treatment;
immunotherapy
- From:
Journal of Chongqing Medical University
2025;50(9):1202-1211
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment(TME)is the cellular environment for tumor development,growth,and metastasis.Adenosine(ADO)is an immunosuppressive metabolic product that is continuously upregulated in TME,with various types and wide distribution of receptors.The complex and dynamic interactions between ADO and tumor cells constantly influence tumor progression.ADO can di-rectly or indirectly promote tumor development and progression by promoting tumor generation and metastasis,mediating the immune escape of tumor,and modulating tumor-infiltrating immune cells.Based on the characteristics of ADOs in TME,this article reviews the latest advances in the dynamic alterations of ADO in TME,in order to provide insights into tumor treatment targeting the ADO pathway.
