Mechanism of glucagon regulating hepatic metabolism in the state of insulin resistance
10.13406/j.cnki.cyxb.003810
- VernacularTitle:胰岛素抵抗状态下胰高糖素对肝脏代谢的调节机制
- Author:
Jingjing YU
1
;
Zhenyu YAO
;
Xiangning ZHOU
;
Lingxi YE
;
Juntong WEI
;
Tao BO
Author Information
1. 内分泌糖脂代谢与脑老化教育部重点实验室/山东第一医科大学附属省立医院内分泌代谢病科,济南 250021
- Keywords:
insulin resistance;
hyperglucagonemia;
liver;
glucose and lipid metabolism;
amino acid
- From:
Journal of Chongqing Medical University
2025;50(9):1178-1186
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon and insulin are the main regulatory factors for blood glucose and jointly maintain the homeostasis of energy me-tabolism in the body,but the internal mechanism of the mutual regulation and influence between them remains complex and unclear.The liver is one of the key target organs for both insulin and glucagon,playing a crucial role in maintaining the homeostasis of glucose and lipid metabolism.Insulin resistance is often accompanied by abnormal glucose and lipid metabolism in the liver,which may affect the functional activity of glucagon in the liver.There is a glucagon-related feedback loop between the liver and the pancreas,known as the"liver-α-cell axis",which may play a critical role in understanding the metabolic effect of glucagon in the state of insulin resis-tance.In addition to the regulation of glucose homeostasis,the physiological action of glucagon has been extended to lipid and amino acid metabolism.Therefore,abnormal regulation of glucagon metabolism may further lead to the imbalance of glucose,lipid,and amino acid metabolism.This article briefly reviews the regulatory mechanism of glucagon in liver glucose homeostasis,lipid metabolism,and amino acid metabolism in physiological condition and the state of insulin resistance.
