Research advances in yttrium-90 microsphere selective internal radiation therapy in treatment of hepatocellular carcinoma
10.13406/j.cnki.cyxb.003873
- VernacularTitle:钇90微球选择性内放射治疗在肝细胞癌治疗中的研究进展
- Author:
Yongle ZHAO
1
;
Honglin CHEN
;
Han ZHANG
;
Xinyue ZHU
;
Zhicheng YANG
;
Maoting TAN
;
Hongyun ZHAO
Author Information
1. 重庆医科大学附属第二医院消化内科,重庆 400010
- Keywords:
yttrium-90 microsphere;
hepatocellular carcinoma;
selective internal radiation therapy
- From:
Journal of Chongqing Medical University
2025;50(8):1035-1041
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is one of the most common causes of cancer-related deaths in China,with hepatocellular carcinoma(HCC)accounting for 75%-85%.Approximately 70%of HCC patients are in the advanced stage at the time of diagnosis and miss the opportunity for radical surgery,leading to a poor prognosis.Yttrium-90 microsphere selective internal radiation therapy(90Y-SIRT),an emerging therapeutic modality,delivers radioactive microspheres via the hepatic artery to target tumors and uses beta radiation for localized tumor ablation.Compared to conventional transarterial chemoembolization and pharmacotherapy,90Y-SIRT shows the advan-tages of significant clinical benefits,good safety profiles,and broad applicability across diverse patient populations.This article re-views the advances in the application of 90Y-SIRT in HCC treatment.
