Research advances in triggering receptor expressed on myeloid cells 2 in the pathogenesis of Alzheimer's disease

VernacularTitle:TREM2在阿尔茨海默病发病机制中的研究进展
Author: Lishu SU ¹ ; Shuohan WANG ; Xinyao QI ; Jing GAO ; Pengjuan XU
Author Information

1. 天津中医药大学中西医结合学院生理教研室,天津 301617
Keywords: Alzheimer's disease; triggering receptor expressed on myeloid cells 2; β-amyloid; Tau; neuroinflammation
From: Journal of Chongqing Medical University 2025;50(8):1016-1020
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a highly destructive neurodegenerative disorder,and due to its complex pathology and insuffi-cient treatment,it is urgent to explore new targets that can directly address the root cause of the disease.In recent years,numerous stud-ies have shown that triggering receptor expressed on myeloid cells 2(TREM2)in microglial cells has the function of delaying the pro-gression of AD,and its abnormality plays a key role in the development and progression of AD,with a potential of being used as a target for the treatment of AD.This article reviews the biological characteristics of TREM2 and discusses its important role in the three major pathological features of AD and its potential as a target for AD treatment,in order to deepen the understanding of the role of TREM2 in AD and provide a theoretical reference for exploring new targets for AD treatment in the future.