Research advances in chemokines and their receptors in cognitive disorders
10.13406/j.cnki.cyxb.003735
- VernacularTitle:趋化因子及其受体在认知障碍性疾病中的研究进展
- Author:
Houyu ZHAO
1
;
Kun LIANG
;
Zeyuan YU
;
Wei DING
;
Yukun WEN
;
Jianming HUANG
;
Yiqun FANG
Author Information
1. 海军军医大学海军特色医学中心/全军航海医学重点实验室,上海 200433
- Keywords:
chemokines;
chemokine receptors;
neuroinflammation;
cognitive impairment;
cognitive disorders
- From:
Journal of Chongqing Medical University
2025;50(7):920-925
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is the main clinical manifestation of many nervous system diseases such as stroke,multiple sclerosis,and neurodegeneration,and neuroinflammation is one of the key mechanisms for the onset of cognitive disorders.Chemokines are a class of highly conserved small-molecule secretory proteins that bind to the corresponding chemokine receptors located on cell mem-brane,activating downstream signaling pathways and playing an important role in cell migration,proliferation,differentiation,and sur-vival.In the central nervous system,chemokines and their receptors are involved in immune response and can exert a certain regulatory effect on neuroinflammation.This article reviews the research advances in chemokines and their receptors in cognitive disorders,in or-der to provide new insights and targets for the early diagnosis and treatment of related diseases.
