Effect of circulating plasma cell on the prognosis of patients with multiple myeloma
10.13406/j.cnki.cyxb.003768
- VernacularTitle:循环浆细胞对多发性骨髓瘤患者预后的影响
- Author:
Miaoyu LI
1
;
Lulu WANG
;
Biao TIAN
;
Wanting XIAO
;
Yanxia WENG
;
Wenrui SUN
;
Hailong TANG
;
Guangxun GAO
Author Information
1. 中国人民解放军空军军医大学第一附属医院血液内科,西安 710032
- Keywords:
multiple myeloma;
circulating plasma cell;
prognosis;
staging system
- From:
Journal of Chongqing Medical University
2025;50(7):905-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of circulating plasma cell(CPC)on the prognosis of multiple myeloma(MM),and to es-tablish and validate a modified CPC-RISS staging system based on CPC and RISS.Methods:A retrospective analysis was performed for the clinical data of 639 treatment-na?ve patients with MM who were treated in Department of Hematology,Xijing Hospital,from January 2006 to June 2023.Peripheral blood smear was used to calculate the percentage of CPC in patients,and the impact of CPC and other related factors on the prognosis of MM patients was analyzed.A CPC-RISS staging system was established based on RISS stage and the percentage of CPC,and the differences in survival and prognosis were analyzed between patients with different stages.Results:Compared with the patients without CPC,detectable CPC was significantly associated with various high-risk factors for MM,and the MM patients with CPC had a lower complete remission rate and shorter overall survival time and progression-free survival time.The modified CPC-RISS staging system was used to classify the patients with MM into four stages,and there were significant differences in median survival time and progression-free survival time between the patients with different stages of MM.Conclusion:The MM pa-tients with the presence of CPC exhibit more aggressive features,worse response to treatment,and a reduction in long-term survival rate.The modified CPC-RISS staging system can effectively predict the prognosis of treatment-na?ve MM patients.
