Research progress on the mechanisms of action of catalpol from Rehmannia glutinosa against glycolipid metabolic disorders and related diseases
10.13406/j.cnki.cyxb.003857
- VernacularTitle:地黄梓醇抗糖脂代谢紊乱相关疾病及其机制的研究进展
- Author:
Meng SUN
1
;
Yang ZHONG
;
Hanjun YANG
;
Dong WAN
;
Huifeng ZHU
Author Information
1. 西南大学药学院/中医药学院,重庆 400715
- Keywords:
catalpol;
glycolipid metabolism;
diabetes complication;
mechanism of action
- From:
Journal of Chongqing Medical University
2025;50(7):849-859
- CountryChina
- Language:Chinese
-
Abstract:
Catalpol,the primary active component of Rehmannia glutinosa,exhibits potent antioxidant and anti-inflammatory effects and regulatory effects on glucose and lipid metabolism.This article systematically reviews recent studies on the impact of catalpol in addressing glycolipid metabolic disorders and related diseases and the underlying mechainsms.Catalpol can correct glucose and lipid metabolism imbalances to prevent the development and progression of diabetes complications including macrovascular and microvascu-lar diseases,through modulating the adenosine 5'-monophosphate-activated protein kinase signaling pathway to regulate lipogenesis and fat oxidation and altering the phosphorylation of forkhead transcription factor 1 and glycogen synthase kinase 3 to influence glyco-gen synthesis and breakdown.Catalpol plays a protective role in the cardio-cerebrovascular system,renal function,and retinal struc-ture and function through mediating signaling pathways such as phosphatidylinositol 3-kinase/protein kinase B and oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1.By suppressing the nuclear factor kappa-light-chain-enhancer of activated B cells pathway and endoplasmic reticulum stress,catalpol can alleviate inflammatory responses,thereby mitigat-ing inflammation-induced insulin resistance and glycolipid metabolic disorders.
