Influence of metabolic-associated fatty liver disease on the development of coronary artery disease in patients with hypertension
10.13406/j.cnki.cyxb.003830
- VernacularTitle:代谢相关脂肪性肝病对高血压患者冠心病发生的影响
- Author:
Yuhang LIU
1
;
Xin YI
;
Yi LONG
Author Information
1. 重庆市中医药学院第一附属医院肝病科,重庆 400021
- Keywords:
metabolic-associated fatty liver disease;
hypertension;
coronary artery disease;
diabetes;
left ventricular ejection fraction;
risk factors
- From:
Journal of Chongqing Medical University
2025;50(6):834-842
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of metabolic-associated fatty liver disease(MAFLD)on the development of coro-nary artery disease(CAD)in patients with hypertension(HT).Methods:A total of 5 344 patients with HT and MAFLD who were hospi-talized in The Second Affiliated Hospital of Chongqing Medical University and University-Town Hospital of Chongqing Medical Univer-sity from November 2011 to November 2021 were enrolled as HT+MAFLD group,and 5 344 HT patients without MAFLD who were hos-pitalized during the same period of time were enrolled as control group.Clinical data were analyzed for both groups.Results:There were significant differences between the HT+MAFLD group and the control group in age(62.6±12.4 years vs.69.1±11.9 years,P<0.05)and the incidence rate of CAD[1 931(36.1%)vs.1 542(28.9%),P<0.05].The multivariate logistic regression analysis showed that MAFLD,age,smoking,type 2 diabetes,left ventricular ejection fraction,and total cholesterol were important predictive factors for CAD in HT patients,with an odds ratio of 2.033,1.050,1.429,1.157,0.983,and 1.078,respectively.After adjustment for related con-founding factors,five regression models were established,and the results showed that MAFLD was an independent risk factor for the de-velopment of CAD in HT patients.Conclusion:HT patients with MAFLD tend to have a relatively high prevalence rate of CAD,and MAFLD is an independent risk factor for the development of CAD in HT patients.
