Neurovascular coupling in patients with depression:a study based on multimodal magnetic resonance imaging
10.13406/j.cnki.cyxb.003781
- VernacularTitle:基于多模态核磁共振探讨抑郁症患者的神经血管耦合研究
- Author:
Yue ZHAO
1
;
Yuanyuan GUO
;
Chenglong LI
;
Juanjuan ZHANG
;
Yanghua TIAN
Author Information
1. 安徽医科大学第一附属医院神经内科,合肥 230022
- Keywords:
depression;
magnetic resonance imaging;
cerebral blood flow;
regional homogeneity;
neurovascular coupling
- From:
Journal of Chongqing Medical University
2025;50(6):778-784
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate altered neurovascular coupling in patients with depression(DEP)using resting-state functional magnetic resonance imaging(MRI)and arterial spin labeling perfusion MRI,as well as its association with depressive symptoms.Methods:Neuropsychological assessment and multimodal MRI scans were performed for 25 DEP patients and 35 healthy controls(HCs).Arterial spin labeling perfusion MRI was used to calculate cerebral blood flow(CBF),and functional MRI was used to calculate regional homogeneity(ReHo).The Pearson correlation coefficient between CBF and ReHo was calculated to obtain neurovascular cou-pling.Results:At the whole-brain level,CBF-ReHo coupling was reduced in DEP patients compared with HCs.At the brain region level,CBF-ReHo coupling was reduced in 26 brain regions in DEP patients,which were mainly located in the visual network,the default network,and the auditory network.The correlation analysis showed that the coupling values of the left suboccipital gyrus,the left angular gyrus,and the left thalamus were negatively correlated with Hamilton Depression Scale score.Conclusion:There is a sig-nificant reduction in neurovascular coupling in DEP patients,which is correlated with the severity of DEP.
