Metabolic reprogramming of polyamines in macrophages and T cells within the tumor microenvironment
10.13406/j.cnki.cyxb.003802
- VernacularTitle:肿瘤微环境内巨噬细胞和T细胞的多胺代谢重编程
- Author:
Zhixu WANG
1
;
Yuxiao SONG
;
Bicheng ZHANG
Author Information
1. 武汉大学人民医院肿瘤中心,武汉 430060
- Keywords:
tumor microenvironment;
macrophages;
T cells;
polyamine metabolism;
metabolic reprogramming;
antitumor therapy
- From:
Journal of Chongqing Medical University
2025;50(6):721-725
- CountryChina
- Language:Chinese
-
Abstract:
In the tumor microenvironment(TME),the metabolic reprogramming of macrophages and T cells plays a critical role in the formation of an immunosuppressive state and tumor immune escape.Polyamines are key signaling molecules and precursors for biosyn-thesis,and the metabolic state of polyamines profoundly regulate the functions of tumor cells and immune cells.Cytokines and other substances within the TME induce the expression of enzymes related to polyamine metabolism,drive the metabolic reprogramming of polyamines,and thus influence macrophage polarization and T cell differentiation;meanwhile,the metabolic reprogramming of poly-amines leads to the competitive depletion of polyamine resources within the TME,promote tumor cells to optimize their metabolic strat-egies for survival advantages,and inhibit the function of immune cells.Therefore,inhibitors of polyamine metabolism may be used as antitumor drugs by regulating metabolic reprogramming.
