Research advances in the interaction between tumor-associated macrophages and T cell subsets
10.13406/j.cnki.cyxb.003843
- VernacularTitle:肿瘤相关巨噬细胞和T细胞亚群相互作用的研究进展
- Author:
Mingbo ZHANG
1
;
Yuxiao SONG
;
Bicheng ZHANG
Author Information
1. 武汉大学人民医院肿瘤中心,武汉 430000
- Keywords:
tumor microenvironment;
tumor-associated macrophages;
T cells;
immunotherapy;
cell communication
- From:
Journal of Chongqing Medical University
2025;50(6):714-720
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages(TAMs)play a pivotal role in the tumor microenvironment and have traditionally been clas-sified into M1 and M2 phenotypes;however,recent studies have revealed considerable internal heterogeneity among these macro-phages,which requires a more detailed classification.T cells play a key role in tumor immunity,and their population dynamics and functional states have a direct impact on therapeutic outcomes.The interactions between TAMs and various T cell subsets,including CD4+T cells,regulatory T cells,and CD8+T cells,have a guiding significance for tumor immunotherapy.Such interactions between TAMs and T cells involve a variety of molecules and signaling pathways,such as programmed death receptor 1 and its ligand,as well as various cytokines and their receptors.Furthermore,exogenous factors,including chemoradiotherapy and infections,can also influence these interactions.Research on the interactions between different macrophage populations and T cell subsets within the tumor immune microenvironment can help to understand immune status and mechanism in lesions,thereby providing new targets and strategies for tu-mor immunotherapy.
